I am a unique number and is even. If you try removing the first letter from me, I become odd.

Which number am I?

"Six" (6)

When you remove the first letter "S" from the word "Six," you are left with the letters "Ix."

"Ix" is the Roman numeral representation of the number 9.

Thus, the wordplay involves the transformation of "Six" (6) into "Ix," representing the number 9, which is an odd number in Roman numerals.